Is NAD supplementation a pure IQ tax?
Professor David Schinlecker of Harvard University in the United States published a study in the authoritative biological magazine “Cell”, which confirmed that NAD+ supplementation can effectively delay the aging of the body through mouse experiments. Since then, the research on nicotinamide adenine dinucleotide and it precursor substances has attracted much attention, not only being widely sought after by major celebrities, but also attracting widespread attention in China.
This discovery provides important hope for human anti-aging, indicating that nicotinamide adenine dinucleotide may become the key to realizing human “immortality”. Multiple research data shows that NAD+ supplementation may help slow down the aging process.
Necessary raw materials for the synthesis of DNA repair enzymes
NAD+ coenzyme that widely distributed in every cell of the human body and is responsible for catalyzing more than 90% of the energy of life activities in the body.
It is also involved in the conversion of nutrients and affects the rate of metabolism.
also a necessary raw material for the synthesis of DNA repair enzymes.
It can activate the 7 major longevity enzyme families in our body and is a magical anti-aging factor. As people age, the nicotinamide adenine dinucleotide content in cells begins to gradually decrease. Promptly increasing the NAD+ level in the body can delay aging and ensure health.
NAD+-dependent aging mechanisms
During aging, NAD+ levels decrease, leading to changes in enzymes involved in nicotinamide adenine dinucleotide degradation and biosynthesis. This decline in nicotinamide adenine dinucleotide levels has linked to the development and progression of age-related diseases, including atherosclerosis, arthritis, hypertension, cognitive decline, diabetes, and cancer. In order to restore nicotinamide adenine dinucleotide levels, people can consume nicotinamide adenine dinucleotide precursors through diet and use small molecule inhibitors to inhibit the activity of nicotinamide adenine dinucleotide degrading enzymes. These approaches considered potential therapeutic strategies to restore nicotinamide adenine dinucleotide levels.
Experimental effects of NAD+ supplementation
Strategies to increase NAD+ have also used to extend lifespan due to age-related diseases. Supplementation with NAD+, NR and/or NMN, is also effective in related models of xeroderma pigmentosum group A,
ataxia telangiectasia, and Cockayne syndrome, and in a nematode model of Werner syndrome, a progeroid disease.
effectively delayed progeria-like phenotypes and extended lifespan. In ataxia-telangiectasia mouse models, NMN treatment significantly increased nicotinamide adenine dinucleotide levels and lifespan. In a mouse model of muscular dystrophy, NR treatment also improved muscle stem cell function by modulating mitochondrial metabolism.
To sum up, NAD has anti-aging effects. And nicotinamide adenine dinucleotide can used in health products, cosmetics, diagnostic reagents and other fields. At the same time, more scientists are needed to conduct further research to verify its safety and effectiveness.
